Article
Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability.
EBioMedicine - 1 Sept 2018
Ferguson Amy, Lyall Laura M, Ward Joey, Strawbridge Rona J, Cullen Breda, Graham Nicholas, Niedzwiedz Claire L, Johnston Keira J A, MacKay Daniel, Biello Stephany M, Pell Jill P, Cavanagh Jonathan, McIntosh Andrew M, Doherty Aiden, Bailey Mark E S, Lyall Donald M, Wyse Cathy A, Smith Daniel J
Abstract excerpt
BACKGROUND: Circadian rhythms are fundamental to health and are particularly important for mental wellbeing. Disrupted rhythms of rest and activity are recognised as risk factors for major depressive disorder and bipolar disorder. METHODS: We conducted a genome-wide association study (GWAS) of low relative amplitude (RA), an objective measure of rest-activity cycles derived from the accelerometer data of 71,500...
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