Article

Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver

2019-06-04

Abstract excerpt

Endoplasmic reticulum (ER) stress-associated cell death is prevalent in various liver diseases. However, the determinant mechanism how hepatocytes survive unresolved stress was still unclear. Interleukin-24 (IL-24) was previously found to promote ER stress-mediated cell death, and yet its expression and function in the liver remained elusive. Here we identified an anti-apoptotic role of IL-24, which transiently ac...

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Literature Corpus work: 23b5dcf9-cf62-55d9-904b-3b8662b0c837
DOI: 10.1101/658666

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