LC-MS/MS-PRM Quantification of IgG glycoforms using stable isotope labeled IgG1 Fc glycopeptide standard

Abstract excerpt

<h4>ABSTRACT</h4> Targeted quantification of proteins is a standard methodology with broad utility, but targeted quantification of glycoproteins has not reached its full potential. The lack of optimized workflows and isotopically labeled standards limits the acceptance of glycoproteomics quantification. In this paper, we introduce an efficient and streamlined chemoenzymatic synthesis of a library of isotopically...

Topics

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• Glycosylation and Glycoproteins Research
• Monoclonal and Polyclonal Antibodies Research
• Protein purification and stability
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

234295ce-e7e9-5224-92c5-7d410b1f974a

DOI

10.1101/2022.08.02.501850