Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SARS‐CoV ‐2 multifaceted interaction with the human host. Part II : Innate immunity response, immunopathology, and epigenetics

16 Sept 2020

Abstract excerpt

The SARS-CoV-2 makes its way into the cell via the ACE2 receptor and the proteolytic action of TMPRSS2. In response to the SARS-CoV-2 infection, the innate immune response is the first line of defense, triggering multiple signaling pathways to produce interferons, pro-inflammatory cytokines and chemokines, and initiating the adaptive immune response against the virus. Unsurprisingly, the virus has developed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19 Clinical Research Studies
Share to Immune responses and vaccinations
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32936531
DOI: 10.1002/iub.2379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SARS‐CoV ‐2 multifaceted interaction with the human host. Part II : Innate immunity response, immunopathology, and epigeneticsPMID 32936531Read ↗

SARS-CoV-2 proteins exploit host’s genetic and epigenetic mediators for the annexation of key host signaling pathways that confers its immune evasion and disease pathophysiologySemantic proximity Read ↗

Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implicationsSemantic proximity Read ↗

IL1β Promotes TMPRSS2 Expression and SARS-CoV-2 Cell Entry Through the p38 MAPK-GATA2 AxisSemantic proximity Read ↗

SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19Semantic proximity Read ↗

Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19.Semantic proximity Read ↗

SARS-CoV-2 infection suppresses ACE2 function and antiviral immune response in the upper respiratory tract of infected patientsSemantic proximity Read ↗

Enrichment of SARS-CoV-2 entry factors and interacting intracellular genes in peripheral immune cellsSemantic proximity Read ↗

ACE2 partially dictates the host range and tropism of SARS-CoV-2Semantic proximity Read ↗

An Immune Epigenetic Insight to COVID-19 InfectionSemantic proximity Read ↗

COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbiditySemantic proximity Read ↗

Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?Semantic proximity Read ↗

SARS-CoV-2, ACE2 expression, and systemic organ invasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.