Article
Dexamethasone and Some Commonly Used Drugs Inhibit MCT8-mediated T3 Transport in Vitro
2021-06-07
Abstract excerpt
Monocarboxylate transporter 8 (MCT8) is the first thyroid hormone transporter that has been linked to a human disease. Besides genetic alterations other factors might impair MCT8 activity. To investigate whether some common drugs can inhibit MCT8-mediated T 3 transport, [ 125 I]T 3 uptake and efflux were measured in COS-7 cells transiently transfected with hMCT8 before and after exposure to increasing concentratio...
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Identifiers and source
- Literature Corpus work
- 22bff095-5a9a-56da-b0e7-b41da685069c
- DOI
- 10.21203/rs.3.rs-564846/v1