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Article

Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.

Transplantation - 1 Dec 2016

Hippen Keli L, Watkins Benjamin, Tkachev Victor, Lemire Amanda M, Lehnen Charles, Riddle Megan J, Singh Karnail, Panoskaltsis-Mortari Angela, Vanhove Bernard, Tolar Jakub, Kean Leslie S, Blazar Bruce R

Abstract excerpt

BACKGROUND: Graft-versus-host disease (GVHD) is a severe complication of hematopoietic stem cell transplantation. Current therapies to prevent alloreactive T cell activation largely cause generalized immunosuppression and may result in adverse drug, antileukemia and antipathogen responses. Recently, several immunomodulatory therapeutics have been developed that show efficacy in maintaining antileukemia responses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27861291
DOI: 10.1097/TP.0000000000001465
PMCID: PMC5175408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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