Article

Intracerebral haemorrhage in Down syndrome: protected or predisposed?

2016-05-12

Abstract excerpt

Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system. Amyloid accumulates in two compartments: as plaques within the brain parenchyma and in vessel walls of the cerebral microvasculature. The parenchymal plaque amyloid is thought to result in an early onset Alzheimer’s disease (AD) dementia, a phenomenon so commo...

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Literature Corpus work: 22937f3a-60e7-5165-93ac-9d88d9456634
DOI: 10.12688/f1000research.7819.1

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