Article
Patterns and severity of vascular amyloid in Alzheimer's disease associated with duplications and missense mutations in APP gene, Down syndrome and sporadic Alzheimer's disease.
Acta neuropathologica - 1 Oct 2018
Mann David M A, Davidson Yvonne S, Robinson Andrew C, Allen Nancy, Hashimoto Tadafumi, Richardson Anna, Jones Matthew, Snowden Julie S, Pendleton Neil, Potier Marie-Claude, Laquerrière Annie, Prasher Vee, Iwatsubo Takeshi, Strydom Andre
Abstract excerpt
In this study, we have compared the severity of amyloid plaque formation and cerebral amyloid angiopathy (CAA), and the subtype pattern of CAA pathology itself, between APP genetic causes of AD (APPdup, APP mutations), older individuals with Down syndrome (DS) showing the pathology of Alzheimer's disease (AD) and individuals with sporadic (early and late onset) AD (sEOAD and sLOAD, respectively). The aim of this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.