Article

Assessing changes in whole-brain structural connectivity in the unilateral 6-hydroxydopamine rat model of Parkinson’s Disease using diffusion imaging and tractography

2024-11-22

Abstract excerpt

I. Parkinson’s disease (PD) is a multifactorial, progressive neurodegenerative disease that has a profound impact on those it afflicts. Its hallmark pathophysiology is characterized by degeneration of dopaminergic neurons in the midbrain which trigger a host of motor and non- motor symptoms. Many preclinical research efforts utilize unilateral lesion models to assess the neural mechanisms of PD and explore new the...

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Literature Corpus work: 228aeb56-1032-5ab9-b172-7bd58ab072aa
DOI: 10.1101/2024.11.22.624742

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