Article

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

2021-02-02

Abstract excerpt

Since the onset of the current COVID-19 pandemic, high priority is given to the development of neutralizing antibodies, as a key approach for the design of therapeutic strategies to countermeasure and eradicate the disease. Previously, we reported the development of human therapeutic monoclonal antibodies (mAbs) exhibiting very high protective ability. These mAbs recognize epitopes on the spike receptor binding do...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2286406c-6ae5-5ccf-a50e-0643752f0edd
DOI: 10.1101/2021.02.02.428995

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 miceDOI 10.1101/2021.02.02.428995Read

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 miceSemantic proximity Read

Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants.Semantic proximity Read

The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against viral variantsSemantic proximity Read

Elucidating the Humoral Immune Response to SARS-CoV-2: Isolation and Characterization of Monoclonal Antibodies from Convalescent COVID-19 PatientsSemantic proximity Read

A potently neutralizing anti-SARS-CoV-2 antibody inhibits variants of concern by binding a highly conserved epitopeSemantic proximity Read

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variantsSemantic proximity Read

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralizationSemantic proximity Read

Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infectionSemantic proximity Read

A broadly reactive antibody targeting the N-terminal domain of SARS-CoV-2 spike confers Fc-mediated protectionSemantic proximity Read

ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodiesSemantic proximity Read

The SARS-CoV-2 neutralizing antibody response to SD1 and its evasion by BA.2.86Semantic proximity Read

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopesSemantic proximity Read