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Chikungunya virus mobilizes the apoptotic machinery to invade host cell defenses

29 Sept 2010

Abstract excerpt

Chikungunya virus (CHIKV) surprised medical workers by a massive outbreak in the Indian Ocean region, reaching Europe in 2007, with exceptional pathologies in infants and elderly patients. Although CHIKV was recently shown to persist in myoblasts, monocytes, and macrophages, we argued that robust antiviral mechanisms, including apoptosis, are essential to ward off the virus. Herein, we tested the capacity of...

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PMID: 20881210
DOI: 10.1096/fj.10-164178

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