Article

Explainable HGT-based framework for predicting human dark kinase protein-pathway associations by leveraging BERT-based embeddings and WGAN-GP

2026-08-04

Abstract excerpt

Discovery of pathway associations and druggability can leverage underutililized dark kinase genes for treating complex diseases (proven for cancer and neurodegeneration), boosted with computational methods. Herein, we employ BERT-based embeddings of proteins and pathways (refined via two-stage transformer and heterogeneous graph transformer) and protein-protein and protein-pathway associations-both positive (curat...

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Literature Corpus work: 21f53b68-8f06-51af-8103-acf78c6c80fb
DOI: 10.64898/2026.07.30.741784

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