Article

Activation of NF-κB/ALDH1A1 Signaling Promotes Non-Mutational Resistance to EGFR-TKIs in Non-Small Cell Lung Cancer

2025-03-11

Abstract excerpt

<title>Abstract</title> <p>This study investigates the molecular mechanisms underlying acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC). First, we utilized NSCLC cells, lung cancer organoids (LCOs), xenograft tumor, and patient-derived orthotopic xenografts tumor models to establish TKI resistance. Their stem cell-li...

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Literature Corpus work: 21d03fa0-7de9-5d92-9c4c-bd3e267b9919
DOI: 10.21203/rs.3.rs-6132050/v1

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