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Article

ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype.

Molecular metabolism - 1 Jul 2017

Haim Yulia, Blüher Matthias, Konrad Daniel, Goldstein Nir, Klöting Nora, Harman-Boehm Ilana, Kirshtein Boris, Ginsberg Doron, Tarnovscki Tanya, Gepner Yftach, Shai Iris, Rudich Assaf

Abstract excerpt

OBJECTIVE: Obesity variably disrupts human health, but molecular-based patients' health-risk stratification is limited. Adipose tissue (AT) stresses may link obesity with metabolic dysfunction, but how they signal in humans remains poorly-characterized. We hypothesized that a transcriptional AT stress-signaling cascade involving E2F1 and ASK1 (MAP3K5) molecularly defines high-risk obese subtype. METHODS: ASK1...

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Identifiers

PMID: 28702328
DOI: 10.1016/j.molmet.2017.05.003
PMCID: PMC5485239

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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