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Mapping brain-behavior space relationships along the psychosis spectrum

20 Jul 2021

Abstract excerpt

Difficulties in advancing effective patient-specific therapies for psychiatric disorders highlight a need to develop a stable neurobiologically grounded mapping between neural and symptom variation. This gap is particularly acute for psychosis-spectrum disorders (PSD). Here, in a sample of 436 PSD patients spanning several diagnoses, we derived and replicated a dimensionality-reduced symptom space across hallmark...

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PMID: 34313219
DOI: 10.7554/elife.66968

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