Article

Structural studies of KCTD1 and its disease-causing mutant P20S provide insights into the protein function and misfunction

2024-06-14

Abstract excerpt

Members of the KCTD protein family play key roles in fundamental physio-pathological processes. A plethora of literature studies have demonstrated their involvement in cancer, neurodevelopmental disorders, and genetic diseases. Despite two decades of intense investigations, the definition of structure-(mis)function relationships for these proteins is still rather limited. Here, we derived atomic-level structural d...

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Literature Corpus work: 212154cd-86f5-5b26-bb6d-a6dc924c6912
DOI: 10.1101/2024.06.14.599007

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