Article

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

2020-01-21

Abstract excerpt

DHTKD1 is the E1 component of the 2-oxoadipic acid dehydrogenase complex (OADHc), which functions in the L-lysine degradation pathway. Mutations in DHTKD1 have been associated with 2-aminoadipic and 2-oxoadipic aciduria, Charcot-Marie-Tooth disease type 2Q (CMT2Q) and eosinophilic esophagitis (EoE). A crystal structure and inhibitors of DHTKD1 could improve the understanding of these clinically distinct disorders...

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Literature Corpus work: a9c42a6e-5688-55ef-8c97-1f84b5ac1e76
DOI: 10.1101/2020.01.20.913012

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