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Randomized clinical trial quality has improved over time but is still not good enough: an analysis of 176,620 randomized controlled trials published between 1966 and 2018

2020-04-27

Abstract excerpt

<h4>Background</h4> Many randomized controlled trials (RCTs) are biased and difficult to reproduce due to methodological flaws and poor reporting. There is increasing attention for responsible research practices including reporting guidelines, but it is unknown whether these efforts have improved RCT quality (i.e. reduced risk of bias). We therefore mapped trends over time in trial publication, trial registration,...

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Literature Corpus work
210afd2e-8c19-5ee2-9fc2-dbc615ad9a8d
DOI
10.1101/2020.04.22.20072371
Open publication

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Randomized clinical trial quality has improved over time but is still not good enough: an analysis of 176,620 randomized controlled trials published between 1966 and 2018DOI 10.1101/2020.04.22.20072371
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