Article
Whole-exome sequencing identifies recurrent SF3B1 R625 mutation and comutation of NF1 and KIT in mucosal melanoma.
Melanoma research - 1 Jun 2017
Hintzsche Jennifer D, Gorden Nicholas T, Amato Carol M, Kim Jihye, Wuensch Kelsey E, Robinson Steven E, Applegate Allison J, Couts Kasey L, Medina Theresa M, Wells Keith R, Wisell Joshua A, McCarter Martin D, Box Neil F, Shellman Yiqun G, Gonzalez Rene C, Lewis Karl D, Tentler John J, Tan Aik Choon, Robinson William A
Abstract excerpt
Mucosal melanomas are a rare subtype of melanoma, arising in mucosal tissues, which have a very poor prognosis due to the lack of effective targeted therapies. This study aimed to better understand the molecular landscape of these cancers and find potential new therapeutic targets. Whole-exome sequencing was performed on mucosal melanomas from 19 patients and 135 sun-exposed cutaneous melanomas, with matched...
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