Bidirectional Wnt signaling between endoderm and mesoderm confers tracheal identity in mouse and human cells

Abstract excerpt

Abstract The periodic cartilage and smooth muscle structures in mammalian trachea are derived from tracheal mesoderm, and tracheal malformations result in serious respiratory defects in neonates. Here we show that canonical Wnt signaling in mesoderm is critical to confer trachea mesenchymal identity in human and mouse. At the initiation of tracheal development, endoderm begins to expressNkx2.1, and then mesoderm...

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