Article

Using the SARS Infection Transcriptional Signature to Identify Potential Treatments for Covid-19

2020-05-20

Abstract excerpt

Gene expression data associated with viral infection of human cell lines is harnessed to define a conserved viral response signature. Drugs that tend to drive gene expression in the direction of the cellular viral response are significantly enriched for those with established antiviral activity. Transcription therefore facilitates a simple and effective filtering of candidate drugs to be put forward for bioassay v...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 206e5857-88fd-51b8-a9fd-7510bdf12e10
DOI: 10.26434/chemrxiv.12327554.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using the SARS Infection Transcriptional Signature to Identify Potential Treatments for Covid-19DOI 10.26434/chemrxiv.12327554.v1Read

Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19Semantic proximity Read

Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approachSemantic proximity Read

A genetically based computational drug repurposing framework for rapid identification of candidate compounds: application to COVID-19Semantic proximity Read

Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2Semantic proximity Read

Identification of new drug treatments to combat COVID19: A signature-based approach using iLINCSSemantic proximity Read

Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug ArsenalSemantic proximity Read

Comparative transcriptome analysis of SARS-CoV, MERS-CoV, and SARS-CoV-2 to identify potential pathways for drug repurposingSemantic proximity Read

Integrative transcriptome analyses empower the anti-COVID-19 drug arsenalSemantic proximity Read

A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infectionSemantic proximity Read

In silico Drug Repurposing to combat COVID-19 based on Pharmacogenomics of Patient Transcriptomic DataSemantic proximity Read

Integrative Transcriptome Analyses Empower the Anti-COVID-19 Drug ArsenalSemantic proximity Read

Rapid Identification of Druggable Targets and the Power of the Phenotype SIMulator for Effective Drug Repurposing in COVID-19Semantic proximity Read