Article

G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover.

1994-12-01

Abstract excerpt

The 545-residue Cln2 protein, like the other G1 cyclins of Saccharomyces cerevisiae, is a very unstable protein. This instability is thought to play a critical role in regulating cell cycle progression. The carboxyl-terminal domains of Cln2 and the other G1 cyclins contain sequences rich in Pro, Glu (and Asp), Ser, and Thr (so-called PEST motifs) that have been postulated to make up the signals that are responsibl...

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Cancer-related Molecular Pathways

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Literature Corpus work: 2024062e-6776-5ab7-8e1b-a3b1a2ab2226
DOI: 10.1128/mcb.14.12.7953

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