Article

Optical Genome Mapping for detecting Homologous Recombination Deficiency (HRD) in human breast and ovarian cancers

2022-12-24

Abstract excerpt

Homologous recombination deficiency (HRD) leads to genomic instability that marks HRD tumor genome with a specific genomic scar. Present in many cancers, HRD is important to be detected as it is associated with a hyper-sensitivity to some classes of drugs, in particular the PARP inhibitors. Here, we investigated the use of structural variants (SVs) detected by the Optical Genome Mapping (OGM) technology as biomark...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20089140-7d7e-5cdf-8de7-fc41c7057ae1
DOI: 10.1101/2022.12.23.521790

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Optical Genome Mapping for detecting Homologous Recombination Deficiency (HRD) in human breast and ovarian cancersDOI 10.1101/2022.12.23.521790Read

Assessing the Phenotype of a Homologous Recombination Deficiency Using High Resolution Array-Based Comparative Genome Hybridization in Ovarian Cancer.Semantic proximity Read

Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis and TreatmentSemantic proximity Read

Homologous Recombination Deficiency in Ovarian and Breast Cancers: Biomarkers, Diagnosis, and TreatmentSemantic proximity Read

Recent Advances in Genomic Approaches for the Detection of Homologous Recombination Deficiency.Semantic proximity Read

Unraveling Homologous Recombination Deficiency in Ovarian Cancer: A Review of Currently Available Testing PlatformsSemantic proximity Read

Homologous recombination deficiency (HRD) testing in ovarian cancer clinical practice: a review of the literatureSemantic proximity Read

Evaluation of optical genome mapping for detecting chromosomal translocation in clinical cytogeneticsSemantic proximity Read

Optical Genome Mapping: A New Tool for Cytogenomic AnalysisSemantic proximity Read

Homologous Recombination Deficiency Scar: Mutations and Beyond—Implications for Precision OncologySemantic proximity Read

Detection of cryptic balanced chromosomal rearrangements using high-resolution optical genome mappingSemantic proximity Read

Multiomics analysis of homologous recombination deficiency across cancer types.Semantic proximity Read

The utility of homologous recombination deficiency biomarkers across cancer typesSemantic proximity Read