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Article

Assessing the Phenotype of a Homologous Recombination Deficiency Using High Resolution Array-Based Comparative Genome Hybridization in Ovarian Cancer.

International journal of molecular sciences - 14 Dec 2023

Magadeeva Svetlana, Qian Xueqian, Korff Nadine, Flörkemeier Inken, Hedemann Nina, Rogmans Christoph, Forster Michael, Arnold Norbert, Maass Nicolai, Bauerschlag Dirk O, Weimer Jörg P

Abstract excerpt

Ovarian cancer (OC) cells with homologous recombination deficiency (HRD) accumulate genomic scars (LST, TAI, and LOH) over a value of 42 in sum. PARP inhibitors can treat OC with HRD. The detection of HRD can be done directly by imaging these genomic scars, or indirectly by detecting mutations in the genes involved in HR. We show that HRD detection is also possible using high-resolution aCGH. A total of 30 OCs...

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Identifiers

PMID: 38139296
DOI: 10.3390/ijms242417467
PMCID: PMC10743768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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