Article

Functional evaluation of a natural AAV capsid liver targeting motif in human hepatocytes

2026-08-20

Abstract excerpt

<h4>Background: </h4> & Aims: Adeno-associated virus (AAV) vectors are attractive delivery vehicles for therapeutic gene delivery, and a notable feature of most AAVs is their natural tropism for the liver, which leads to significant hepatic uptake following systemic administration. In previous work, we identified 266G as a conserved motif on a variable region on the capsid of many commonly used AAV variants that c...

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Literature Corpus work: bc9e6534-f4f3-58a1-b5b4-71ef6581f2a1
DOI: 10.64898/2026.08.20.745184

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