Article

Conditional distribution modeling as an alternative method for covariates simulation: comparison with joint multivariate normal and bootstrap techniques

2020-11-02

Abstract excerpt

Clinical trial simulation (CTS) is a valuable tool in drug development. To obtain realistic scenarios, the subjects included in the CTS must be representative of the target population. Common ways of generating virtual subjects are based upon bootstrap (BS) procedures or multivariate normal distributions (MVND). Here, we investigated the performance of an alternative method based on conditional distributions (CD)....

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Literature Corpus work: 4a5af6b6-eea3-51a9-8098-3cdc5de9510d
DOI: 10.1101/2020.11.01.363325

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