Article

A paralog of Pcc1 is the fifth core subunit of KEOPS complex in Archaea

2022-08-30

Abstract excerpt

<h4>ABSTRACT</h4> In Archaea and Eukaryotes, the synthesis of a universal tRNA modification, t 6 A, is catalyzed by the KEOPS complex composed of Kae1, Bud32, Cgi121 and Pcc1. A fifth subunit, Gon7, is found only in Fungi and Metazoa. Mutations in all five genes encoding human KEOPS subunits leads to Galloway-Mowat syndrome, a severe genetic disease causing childhood lethality. Here, we describe the discovery an...

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Literature Corpus work: 1fc81f84-1871-5e92-ace3-fecb66079a3c
DOI: 10.1101/2022.08.30.505904

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