Article

A cone opsin double knockout mouse reveals long-term cone survival and provides a platform for gene therapy

2026-06-17

Abstract excerpt

<title>Abstract</title> <p>Mutations in cone opsin-encoding genes are associated with colorblindness and retinal disease. In certain forms of blue cone monochromacy (BCM) in humans, a viable cone population that does not express cone opsin is present in the retina. Double cone opsin knockout (DKO) mouse models of BCM have been developed previously using gene trap insertion in one or both opsin genes. Here, we rep...

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Literature Corpus work: 1f6bdf96-8230-5ee4-b7d5-9e55d88b67e2
DOI: 10.21203/rs.3.rs-9768355/v1

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