Article

Lactate aggravates myocardial Ischemia-Reperfusion injury through SLC39A14-mediated ferroptosis

2024-07-15

Abstract excerpt

<title>Abstract</title> <p>Ferroptosis, a new form of iron-dependent regulated cell death, is driven by lipid peroxidation, playing a role in various pathogenic processes. Although the role of ferroptosis in myocardial ischemia-reperfusion injury (MIRI) has been intensively studied, the underlying molecular mechanisms remained largely unclear. Here, we showed that lactate participated in ferroptosis induced by hy...

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Literature Corpus work: 1f262745-b548-5ce4-b7ff-2aa6685948e5
DOI: 10.21203/rs.3.rs-4623586/v1

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