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miRNA-541-5p regulates myocardial ischemia–reperfusion injury by targeting ferroptosis

15 Jan 2025

Abstract excerpt

BACKGROUND: This article aims to use high-throughput sequencing to identify miRNAs associated with ferroptosis in myocardial ischemia-reperfusion injury, select a target miRNA, and investigate its role in H9C2 cells hypoxia-reoxygenation injury. METHODS: SD rats and H9C2 cells were used as subjects. ELISA kits quantified MDA, SOD, GSH, LDH, and ferritin levels. TTC staining evaluated infarction size. HE staining...

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PMID: 39815273
DOI: 10.1186/s13019-024-03260-2

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