Article

Zinc transporter somatic gene mutations cause primary aldosteronism

2022-07-25

Abstract excerpt

Primary aldosteronism (PA) is the most common form of endocrine hypertension and effects one in 50 adults. PA is characterized by inappropriately elevated aldosterone production via renin-independent mechanisms. Driver somatic mutations for aldosterone excess have been found in approximately 90% of aldosterone-producing adenomas (APAs). Using next-generation sequencing, we identified recurrent in-frame deletions i...

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Literature Corpus work: 1f149a30-6df4-52d9-b13e-2f4bfe2f2fc8
DOI: 10.1101/2022.07.25.501443

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