Article

Manganese Enhances DNA- or RNA-Mediated Innate Immune Response by Inducing Phosphorylation of TANK-Binding Kinase 1

2022-03-21

Abstract excerpt

Transition metals are essential for various physiological processes, but their roles in innate immunity have not been fully explored. Here, we found that among seven tested metal ions, only manganese (Mn) significantly enhanced DNA-mediated IFN-α, IFN-β, and IFN-λ1 production. Microarray analysis demonstrated that 351 genes were highly upregulated by Mn<sup>2+</sup>, and those genes were involved in multiple biolo...

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Literature Corpus work: 1eebaef4-f5f8-5441-8939-4edc4a7f03e1
DOI: 10.2139/ssrn.4063315

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