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Manganese Mediates Its Antiviral Functions in a cGAS-STING Pathway Independent Manner

28 Feb 2023

Abstract excerpt

The innate immune system is the first line of host defense sensing viral infection. Manganese (Mn) has recently been found to be involved in the activation of the innate immune DNA-sensing cGAS-STING pathway and subsequent anti-DNA virus function. However, it is still unclear whether Mn2+ mediates host defense against RNA viruses. In this study, we demonstrate that Mn2+ exhibited antiviral effects against various...

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PMID: 36992355
DOI: 10.3390/v15030646

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