Article
Molecular signature of neutrophils in antiphospholipid syndrome based on epigenomic and transcriptome analysis
2025-10-07
Abstract excerpt
<h4>Background</h4> Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thrombosis and pregnancy loss. Recent studies indicate that neutrophils, particularly neutrophil extracellular traps (NETs), contribute to the development and progression of APS. However, the precise underlying mechanisms remain unclear. <h4>Methods</h4> To address this, we analyzed epigenome and transcriptome data to...
Topics
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- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- interferon and immune responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Renal Diseases and Glomerulopathies
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
Identifiers and source
- Literature Corpus work
- 1eafc860-19ef-5358-988c-9cc0ca1e1aa5
- DOI
- 10.1101/2025.10.03.680196
