Article

Synergistic Inhibitory Effect of Ionizing Radiation Combined With Imatinib on Gastrointestinal Stromal Tumor Cell and Its Mechanism

2020-11-12

Abstract excerpt

<h4>Background: </h4> RT is considered insensitive to GIST,However, recently, the effective clinical practice of RT in GIST has been reported,The purpose of this study was to clarify the synergistic effect of RT combined with IM on GIST and the potential molecular mechanism.MethodsThe expression of DNA repair genes related to IR in 100 patients with GIST and their matched tissues was studied by IHC.The relationshi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1e74556c-3293-51b3-9d76-af01a6312e46
DOI: 10.21203/rs.3.rs-103663/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synergistic Inhibitory Effect of Ionizing Radiation Combined With Imatinib on Gastrointestinal Stromal Tumor Cell and Its MechanismDOI 10.21203/rs.3.rs-103663/v1Read

Biological Mechanisms to Reduce Radioresistance and Increase the Efficacy of Radiotherapy: State of the ArtSemantic proximity Read

Radiation-induced signaling pathways that promote cancer cell survival (Review)Semantic proximity Read

125I Low Dose Rate Radiation Increases Radiotherapy Sensitivity on Esophageal Cancer Cells via Multiple MechanismsSemantic proximity Read

YAP1-TEAD4-DKK1 is an effective target for inhibiting radiation resistance in esophageal squamous carcinoma and activation of the pathway may be related to poor prognosis of patientsSemantic proximity Read

Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancerSemantic proximity Read

Cell Signaling Pathways That Promote Radioresistance of Cancer CellsSemantic proximity Read

EZH2 targeting to improve the sensitivity of acquired radio-resistance bladder cancer cellsSemantic proximity Read

Radioresistance in Hepatocellular Carcinoma: Biological Bases and Therapeutic ImplicationsSemantic proximity Read

Effect of therapies-mediated modulation of telomere and/or telomerase on cancer cells radiosensitivitySemantic proximity Read

KZ02 enhances the radiosensitivity of BRAF-mutated CRC in vitro and in vivo.Semantic proximity Read

miR-199b-3p Promotes Radiation-induced Oral Mucositis via DDIT4-mediated mTOR Signal PathwaySemantic proximity Read

Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivitySemantic proximity Read