Article

MSC-delivered High-Affinity Variants of soluble PD1 lead to tumour regression

2025-12-08

Abstract excerpt

Immune checkpoint therapies aim to restore anti-tumour immunity by blocking inhibitory signals that suppress T-cell activation. The most effective current strategies use humanised antibodies targeting PD1 or its ligand PDL1. However, due to their large size, antibodies often exhibit limited tissue diffusion, resulting in poor penetration into solid tumours. To address this challenge, we developed a novel checkpoin...

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Identifiers and source

Literature Corpus work: 1e208a37-9ea7-556a-b212-4a5530316503
DOI: 10.64898/2025.12.04.692338

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