Article
Detecting Rare Variants and Heteroplasmy of Mitochondrial DNA from High-Throughput Sequencing in Patients with Coronary Artery Disease.
Medical science monitor : international medical journal of experimental and clinical research - 2 Nov 2020
Jia Qian, Xu Lu, Shen Juan, Wei Yanping, Xu Huaiqian, Shi Jinlong, Jia Zhilong, Zhao Xiaojing, Liu Chunlei, Zhong Qin, Tian Yaping, He Kunlun
Abstract excerpt
BACKGROUND Although mutations and dysfunction of mitochondrial DNA (mtDNA) are related to a variety of diseases, few studies have focused on the relationship between mtDNA and coronary artery disease (CAD), especially the relationship between rare variants and CAD. MATERIAL AND METHODS Two-stage high-throughput sequencing was performed to detect mtDNA variants or heteroplasmy and the relationship between them and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.