Article

High-throughput RNAi screen identifies ILK as a target to overcome intrinsic EGFR-TKI resistance of lung squamous carcinoma

2019-11-19

Abstract excerpt

<title>Abstract</title> <p>Although targeted therapy has made a significant efficacy in lung adenocarcinoma, there are still no effective targeted drugs for lung squamous cell carcinoma (SqCC). Moreover, immunotherapy only prolonged the OS of lung SqCC for less than 5 months, so till now, chemotherapy and radiotherapy are still the main treatments of advanced SqCC. Lung SqCC patients express higher epithelial gro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1ddd1697-df1b-53ee-8fd0-142e6b63b680
DOI: 10.21203/rs.2.17492/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High-throughput RNAi screen identifies ILK as a target to overcome intrinsic EGFR-TKI resistance of lung squamous carcinomaDOI 10.21203/rs.2.17492/v1Read

Signaling pathways and targeted therapies in lung squamous cell carcinoma: mechanisms and clinical trialsSemantic proximity Read

Identification of biomarkers, pathways and potential therapeutic targets for EGFR-TKI resistance in non-small-cell lung cancerSemantic proximity Read

MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells.Semantic proximity Read

[Progress on the Study of Targeting FGFR in Squamous Non-small Cell Lung Cancer].Semantic proximity Read

Activation of NF-κB/ALDH1A1 Signaling Promotes Non-Mutational Resistance to EGFR-TKIs in Non-Small Cell Lung CancerSemantic proximity Read

The advanced research of immunotherapy in Epidermal growth factor receptor mutation-positive non-small cell lung cancer.Semantic proximity Read

RNAi Targeting-STIL Suppresses Cell Growth and Induces Apoptosis of Lung Cancer NCI-H1299 Cells via Inactivation of Akt/SAPK/TAK1 PathwaysSemantic proximity Read

What is the impact of ITGβ8 on NSCLC: A systematic studySemantic proximity Read

EREG increases stemness associated genes expression and promotes Chemoresistance of non-small cell lung cancer via ERK signalingSemantic proximity Read

Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinomaSemantic proximity Read

A novel inhibitor isoimperatorin targeting YWHAZ suppresses human lung adenocarcinoma activity by activating autophagySemantic proximity Read

TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through MerlinSemantic proximity Read