Article

Genomic loci mispositioning in <i>Tmem120a</i> knockout mice yields latent lipodystrophy

2021-04-12

Abstract excerpt

Little is known about the proteins that direct the highly conserved patterns of spatial genome organisation in fat. Here we report that adipocyte-specific knockout of the gene encoding nuclear envelope protein Tmem120a disrupts fat genome organisation, thus causing a novel lipodystrophy syndrome. Tmem120a deficiency broadly suppresses lipid metabolism pathway gene expression and induces myogenic gene expression by...

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Literature Corpus work: 4009f7d2-349a-5b72-a763-449782535f1d
DOI: 10.1101/2021.04.12.439495

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