Article

Precision Oncology Insights into WNT Pathway Alterations in FOLFOX-Treated Early-Onset Colorectal Cancer in High-Risk Populations

2025-08-07

Abstract excerpt

<h4>Background</h4> Early-onset colorectal cancer (EOCRC), defined as diagnosis before age 50, is rising rapidly and disproportionately affects high-risk populations, including Hispanic/Latino (H/L) individuals. Although FOLFOX is a standard first-line chemotherapy for microsatellite stable (MSS) CRC, its efficacy and impact on tumor genomics in EOCRC remain understudied. Given the central role of WNT signaling i...

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Literature Corpus work: 1db72340-eeb6-5ef8-8feb-7551d095e074
DOI: 10.1101/2025.08.02.25332877

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