Article

Increase of cell surface vimentin (CSV) is associated with vimentin network disruption and subsequent stress-induced premature senescence (SIPS) in human chondrocytes

2023-05-09

Abstract excerpt

Accumulation of dysfunctional chondrocytes has detrimental consequences on the cartilage homeostasis and is thus thought to play a crucial role during the pathogenesis of osteoarthritis (OA). However, the underlying mechanisms of phenotypical alteration in chondrocytes are incompletely understood. Here, we provide evidence that disruption of the intracellular vimentin network and consequent phenotypical alteration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d96fb4d-188d-5e4b-91f8-a6891a408c4f
DOI: 10.1101/2023.05.08.539821

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Increase of cell surface vimentin (CSV) is associated with vimentin network disruption and subsequent stress-induced premature senescence (SIPS) in human chondrocytesDOI 10.1101/2023.05.08.539821Read

Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytesSemantic proximity Read

Senescence-associated alterations of cytoskeleton: extraordinary production of vimentin that anchors cytoplasmic p53 in senescent human fibroblastsSemantic proximity Read

Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblastsSemantic proximity Read

Cellular senescence in knee osteoarthritis: molecular mechanisms and therapeutic implicationsSemantic proximity Read

Vimentin: from a cytoskeletal protein to a critical modulator of immune response and a target for infectionSemantic proximity Read

Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3Semantic proximity Read

Mechanistic Insights Into Overloading‐Induced Terminal Differentiation of TMJ Condylar Cartilage at the Single Cell LevelSemantic proximity Read

Vimentin filaments interact with the actin cortex in mitosis allowing normal cell divisionSemantic proximity Read

Do chondrocytes undergo "activation" and "transdifferentiation" during the pathogenesis of osteoarthritis? A review of the ultrastructural and immunohistochemical evidence.Semantic proximity Read

Proteome and cytoskeleton responses in osteosarcoma cells with reduced OXPHOS activity.Semantic proximity Read

Nuclear Accumulation of Globular Actin as a Cellular Senescence MarkerSemantic proximity Read

Unbounded Cell Growth and Proteome Imbalance in Doxorubicin-Induced Senescent RPE-1 CellsSemantic proximity Read