Article

Plasmodium falciparum genetic factors rather than host factors are likely to drive resistance to ACT in Ghana

2020-06-29

Abstract excerpt

<h4>Background: </h4> Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner drugs may affect treatment outcome. Mutations in pfmdr1 gene is linked to reduced parasite susceptibility to amodiaquine and lumefantrine. In addition, the potency of the partner drugs in v...

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Literature Corpus work: 1d6f866c-4b56-5bff-a3b3-b475e3ac9760
DOI: 10.21203/rs.3.rs-25966/v3

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