Article

Genome-wide RNA binding analysis of <i>C9orf72</i> poly(PR) dipeptides

2022-10-11

Abstract excerpt

An intronic GGGGCC repeat expansion in C9orf72 is a common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. The repeats are transcribed in both sense and antisense directions to generate distinct dipeptide repeat proteins, of which poly(GA), poly(GR) and poly(PR) have been implicated in contributing to neurodegeneration. Poly(PR) binding to RNA may contribute to toxicity, but analysis o...

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Literature Corpus work: 1d6ca380-09fc-58f9-824b-88ce578b2609
DOI: 10.1101/2022.10.10.511318

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