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Article

The validation and clinical implementation of BRCAplus: a comprehensive high-risk breast cancer diagnostic assay.

PloS one - 1 Jan 2014

Chong Hansook Kim, Wang Tao, Lu Hsiao-Mei, Seidler Sara, Lu Hong, Keiles Steven, Chao Elizabeth C, Stuenkel A J, Li Xiang, Elliott Aaron M

Abstract excerpt

Breast cancer is the most commonly diagnosed cancer in women, with 10% of disease attributed to hereditary factors. Although BRCA1 and BRCA2 account for a high percentage of hereditary cases, there are more than 25 susceptibility genes that differentially impact the risk for breast cancer. Traditionally, germline testing for breast cancer was performed by Sanger dideoxy terminator sequencing in a reflexive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24830819
DOI: 10.1371/journal.pone.0097408
PMCID: PMC4022661

Genes

BRCA1
BRCA2
CDH1
PTEN
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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