Article

DNA Methylation Modulation by 5-Azacytidine Regulates EMT Markers and Reduces Invasiveness in Docetaxel-Resistant Prostate Cancer Cells

2025-11-13

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Metastatic castration-resistant prostate cancer (mCRPC) is associated with poor prognosis and high mortality, largely due to the emergence of androgen and chemotherapy resistance. Resistance to docetaxel occurs in nearly 50% of patients and remains a major clinical challenge. DNA methylation is known to contribute to therapy resistance through gene silencing...

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Literature Corpus work: 1d4e9061-3030-5609-91b2-1160aa7d5e9c
DOI: 10.21203/rs.3.rs-7889796/v1

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