Targeting the LY6H-PI3K/AKT Autophagy Axis Suppresses HCC Malignancy and Reveals a Druggable Vulnerability

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) is a highly lethal malignancy worldwide, with its initiation and progression closely tied to dysregulated autophagy. Lymphocyte antigen 6 family member H (LY6H), a glycosylphosphatidylinositol-anchored protein, is aberrantly expressed in multiple cancers, yet its functions and mechanisms in HCC remain undefined. Here, we demonstrate that LY6H is markedly u...

Topics

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• Autophagy in Disease and Therapy
• Catalytic Domain
• Gene Knockdown Techniques
• Hep G2 Cells
• Histone Deacetylase Inhibitors Research
• Phosphoprotein Phosphatases
• Protein Processing, Post-Translational
• Protein Subunits

Identifiers and source

Literature Corpus work

1d3b23fa-bded-5455-9fde-dc290982d94d

DOI

10.21203/rs.3.rs-7392770/v1