Article

Preservation of co-expression defines the primary tissue fidelity of human neural organoids

2023-03-31

Abstract excerpt

Human neural organoid models offer an exciting opportunity for studying often inaccessible human-specific brain development; however, it remains unclear how precisely organoids recapitulate fetal/primary tissue biology. Here, we characterize field-wide replicability and biological fidelity through a meta-analysis of single-cell RNA-sequencing data for first and second trimester human primary brain (2.95 million ce...

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Literature Corpus work: 0b877b75-c3be-512a-8f97-1f579f7ce40d
DOI: 10.1101/2023.03.31.535112

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