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Rapid emergence of HCMV drug resistance in immunocompromised paediatric patients detected using target enrichment and deep sequencing

2016-05-27

Abstract excerpt

<h4>Background</h4> Cytomegalovirus can cause fatal disease in immunocompromised patients. With the advent of new anti-HCMV drugs there is interest in using virus sequence data to monitor resistance and identify new mutations. <h4>Methods</h4> We used target-enrichment to deep sequence HCMV DNA from 11 immunosuppressed paediatric patients receiving single or combination anti-HCMV treatment, serially sampled over...

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Literature Corpus work
1c828b8e-a2fd-59e2-8bfb-a0dee575f948
DOI
10.1101/055814
Open publication

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Rapid emergence of HCMV drug resistance in immunocompromised paediatric patients detected using target enrichment and deep sequencingDOI 10.1101/055814
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