Article

Patient-specific logic models of signaling pathways from screenings on cancer biopsies to prioritize personalized combination therapies

2018-09-21

Abstract excerpt

Mechanistic modeling of signaling pathways mediating patient-specific response to therapy can help to unveil resistance mechanisms and improve therapeutic strategies. Yet, creating such models for patients, in particular for solid malignancies, is challenging. A major hurdle to build these models is the limited material available, that precludes the generation of large-scale perturbation data. Here, we present an...

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Literature Corpus work: 1c5ff745-bfa2-5c47-b7f1-a627f9110199
DOI: 10.1101/422998

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