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Article

Uncovering potential interventions for pancreatic cancer patients via mathematical modeling.

Journal of theoretical biology - 7 Sept 2022

Plaugher Daniel, Aguilar Boris, Murrugarra David

Abstract excerpt

Pancreatic Ductal Adenocarcinoma (PDAC) is widely known for its poor prognosis because it is often diagnosed when the cancer is in a later stage. We built a Boolean model to analyze the microenvironment of pancreatic cancer in order to better understand the interplay between pancreatic cancer, stellate cells, and their signaling cytokines. Specifically, we have used our model to study the impact of inducing four...

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Identifiers

PMID: 35752283
DOI: 10.1016/j.jtbi.2022.111197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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